The full article title: Negro R et al, Increased Pregnancy Loss Rate in Thyroid Antibody Negative Women with TSH Levels between 2.5 and 5.0 in the First Trimester of Pregnancy.
This study investigated the rate of preterm (early) delivery and pregnancy loss in women without hypothyroidism but with a TSH in the upper range of normal (TSH 2.5-5 mIU/L). In 2007, The Endocrine Society recommended that all women on thyroid hormone replacement therapy (levothyroxine) have TSH less than 2.5 mIU/L during the first trimester and less than 3 mIU/L throughout pregnancy. However, the definition of a normal TSH during pregnancy has been changing over time. In the non-pregnant woman, normal thyroid function is attributed to a TSH level in the normal range, usually 0.5 – 5 mIU/L. For at least the first half of pregnancy, the fetus gets thyroid hormone from the mother, so it is important that the mother has normal thyroid function during this time. Thyroid hormone is essential for a baby to develop normally during pregnancy. Table of Contents | PDF File for Saving and Printingįirst Trimester TSH levels between 2.5 and 5.0 are associated with increased pregnancy loss Summaries for Patients from Clinical Thyroidology (July 2010) A publication of the American Thyroid Association
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